This study aims to define the approach to be taken to Strategic Digital Cooperation between the European Union (EU) and Latin America and the Caribbean (LAC), addressing opportunities for digital integration, technology transfer, sustainable innovation and joint policy-making, through a review of the regulatory framework for the digital sphere and the European Digital Decade programme developed in the EU. It also examines the background to relations between the EU and Latin America and the Caribbean, how subregional integration processes have addressed digital transformation in LAC, and the differences and similarities between the two regions, analysing the importance, necessity and benefits of achieving Strategic Digital Cooperation between the EU and LAC. Such cooperation should lead to the creation and implementation of a Digital Integration Agenda for Latin America and the Caribbean, promoted, led and driven by the EU as a solid integration process that seeks global leadership in digital matters and strengthens the ties of cooperation between the two regions.